Skip to main content
. Author manuscript; available in PMC: 2021 Mar 22.
Published in final edited form as: Chem Biol Drug Des. 2017 Nov 3;91(2):491–504. doi: 10.1111/cbdd.13110

FIGURE 5.

FIGURE 5

(a) Pairwise RMSD of the alpha carbons along the backbone of the snapshots used for the MED versus the FGF23 X-ray structure (PDB ID: 2P39). (b) Structures derived from conformational cluster analysis of an MD simulation submitted to the FTMap web server for identification of possible binding sites of the FGF23 antagonist molecules. Regions predicted to form interactions with FGFR are colored in orange, cyan, yellow, and gray surface. An FTMap center associated with a possible binding pocket distal to the predicted protein–protein interface is colored in transparent green. The possible binding sites identified by FTMap are shown as spheres. The black spheres correspond to the possible sites found on representative cluster A, red spheres are for cluster B, green spheres are for cluster C, and blue spheres are for cluster D