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. Author manuscript; available in PMC: 2021 Mar 22.
Published in final edited form as: Chem Biol Drug Des. 2017 Nov 3;91(2):491–504. doi: 10.1111/cbdd.13110

FIGURE 7.

FIGURE 7

(a) Distributions of the estimated binding affinities from the MM/PBSA for the subset of dockings examined in the MED of ZINC13407541. (b) The distribution of the best binding pocket per the MM/PBSA analysis (cyan), the possible distal pocket for ZINC13407541 (green), and the worst possible pocket (blue dash). E and J correspond to the region where FGF23:FGFR interactions are predicted to form. (c) The best docked pose (cyan) and the corresponding FGF23 side-chain conformations (also in cyan) with the worst ligand pose (blue) with the associated side-chain conformations (also in blue)