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. 2019 Jan 28;71(3):460–467. doi: 10.1002/art.40731

Figure 1.

Figure 1

Group 1 innate lymphoid cells (ILC1s), natural cytotoxicity receptor–negative (NCR−) group 3 ILCs (ILC3s), and NCR+ ILC3s are expanded in synovial fluid (SF) of patients with juvenile idiopathic arthritis (JIA). A and B, Representative flow cytometry plots (A) and summary scatterplots with bar charts (B) showing the frequency of total ILCs (defined as lineage−CD127+CD161+) within total CD45+ live cells in peripheral blood mononuclear cells (PBMCs) from healthy adults (aHC; n = 12), PBMCs from healthy children (cHC; n = 4), PBMCs from JIA patients (total n = 17; 8 with enthesitis‐related arthritis [ERA], 4 with oligoarticular JIA [Oligo], 2 with polyarticular JIA [Poly], and 3 with psoriatic arthritis [PsA]), and SF mononuclear cells (SFMCs) from JIA patients (total n = 38; 17 with ERA, 13 with oligoarticular JIA, 3 with polyarticular JIA, and 5 with PsA). C–G, Representative flow cytometry plots (C) and summary scatterplots with bar charts (D–G) showing the frequency of ILC1s (defined as lineage–CD127+CD161+c‐Kit−chemoattractant receptor–like molecule expressed on Th2 cells–negative [CRTH2−]) (D), group 2 ILCs (ILC2s; defined as lineage−CD127+CD161+CRTH2+) (E), NCR− ILC3s (defined as lineage−CD127+CD161+c‐Kit+CRTH2−NKp44−) (F), and NCR+ ILC3s (defined as lineage−CD127+CD161+c‐Kit+CRTH2−NKp44+) (G) within total ILCs in PBMCs from healthy adults (n = 12), PBMCs from healthy children (n = 4), PBMCs from JIA patients (total n = 17; 8 with ERA, 4 with oligoarticular JIA, 2 with polyarticular JIA, and 3 with PsA), and SFMCs from JIA patients (total n = 38; 17 with ERA, 13 with oligoarticular JIA, 3 with polyarticular JIA, and 5 with PsA). Symbols represent individual patients; bars show the mean ± SEM. Significance was determined by Kruskal‐Wallis test with Dunn's multiple comparison test.