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. Author manuscript; available in PMC: 2021 Mar 22.
Published in final edited form as: Science. 2021 Jan 21;371(6532):eabc1944. doi: 10.1126/science.abc1944

Fig. 4. Quantifying the diverse metastatic phenotypes of clonal populations directly from cell lineages.

Fig. 4.

(A) Theoretical continuum of metastatic phenotypes, spanning non-metastatic (never exiting the primary site) to highly metastatic (frequently transitioning between tumors; arrows). Ancestral metastatic events between tissues leave clear phylogenetic signatures (yellow stars). (B) Example clonal populations that illustrate the wide range of metastatic phenotypes observed: a non-metastatic population that never exits the primary site (CP029); a moderately metastatic population that infrequently transitions between different tissues (CP019); and a frequently metastasizing population with closely related cells residing in different tissues (CP013). Cells colored by tissue as in Fig. 1E; metastatic phenotypes scored by the TreeMetRate. (C) The distribution of TreeMetRates for each clonal population. (D) The distributions of single-cell-resolution metastatic phenotypes (scMetRates) for each clonal population, rank-ordered by TreeMetRate; median scMetRate indicated in black.