Table 3.
Cerebral metabolic rate of oxygen (CMRO2) during wakefulness and EEG-verified sleep.
| Participant(sex, age) | Pre-sleep (W1)a | ‘eyes closed’ period (EC)b | Post-sleep (W2)a | % changeEC vs.W1 | % changeW2 vs.W1 |
|---|---|---|---|---|---|
| S01c (M, 40y) | 127 (3) | 107 (3) | 116 (4) | −16 | −8 |
| S02c (M, 35y) | 129 (3) | 111 (4) | 118 (1) | −14 | −9 |
| S03 (M, 22y) | 119 (6) | 108 (2) | 113 (6) | −9 | −5 |
| S04 (M, 23y) | 121 (1) | 114 (1) | 118 (1) | −6 | −2 |
| S05 (M, 32y) | 95 (4) | 87 (4) | 102 (1) | −9 | +8 |
| S06 (F, 31y) | 129 (3) | 133 (2) | 140 (4) | +3 | +8 |
| S07c (M, 36y) | 104 (2) | 79 (2) | 98 (2) | −24 | −6 |
| S08c (F, 24y) | 111 (3) | 92 (1) | 102 (1) | −17 | −9 |
Note: CMRO2 expressed in µmol O2/min/100 g brain tissue. Standard deviations are indicated in parentheses.
aCMRO2 was averaged over the pre-sleep wakefulness period and over the last 5 min of the post-sleep wakefulness period, respectively in W1 and W2.
bThe lowest CMRO2 averaged over 5-min intervals.
cThe subject self-assessed to have been asleep during the ‘eyes closed’ period, and onset of sleep was confirmed by EEG for this dataset.
W1: initial ‘eyes open’ period, constraint to stay awake; EC: ‘eyes closed’ period, allocated to sleep; W2: final ‘eyes open’ awake period.