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Proposed mechanism of intercellular transport of mitochondria from mesenchymal stem cells (MSC) to neurons via tunneling nanotubes (TNT). Ischemia damages neuronal mitochondria, but also induces an inflammatory response that increases TNFAIP2 and Miro 1 production. This, in turn, increases mitochondrial motility and the transfer of healthy mitochondria from MSC to neurons, potentially sparing neurons from apoptosis.
