Table 1.
[11C]UCB-J PET imaging kinetics of the 1- and 2-tissue compartment models in naïve rats.
| Brain region | VT (ml/cm3) | SE of VT | AIC | K1 (ml/cm3/min) | VT(2T) = a*VT(1T) + b | |
|---|---|---|---|---|---|---|
| Striatum | 1T2T | 44.6 (10.3) 46.6 (13.0) | 4.9 (3.1) 4.5 (4.1) | 40.7 (30.9) 30.4 (30.9) | 1.7 (1.3) 3.4 (3.0) | a = 1.23b = −8.32 |
| Frontal cortex | 1T2T | 41.8 (8.1) 43.3 (8.8) | 4.9 (1.1) 4.9 (1.8) | 39.4 (18.3) 31.1 (17.2) | 1.2 (0.9) 2.4 (2.6) | a = 1.72b = −5.57 |
| Hippocampus | 1T2T | 41.8 (9.6) 43.9 (10.1) | 5.2 (0.5) 5.3 (1.2) | 46.7 (14.0) 36.7 (11.8) | 1.3 (0.9) 2.8 (2.6) | a = 1.22b = −6.85 |
| Thalamus | 1T2T | 46.2 (10.8) 48.2 (10.9) | 5.0 (0.9) 4.9 (1.0) | 42.7 (18.7) 32.3 (17.3) | 1.6 (1.2) 3.1 (2.6) | a = 1.19b = −6.69 |
| Amygdala | 1T2T | 38.0 (9.1) 39.9 (9.6) | 5.3 (0.5) 4.9 (0.8) | 46.7 (13.0) 37.1 (11.2) | 1.1 (0.8) 2.8 (2.6) | a = 1.22b = −6.44 |
| Cerebellum | 1T2T | 31.6 (8.2) 33.5 (8.1) | 5.5 (1.2) 5.1 (1.3) | 50.6 (17.2) 36.1 (21.9) | 1.5 (1.2) 3.1 (2.7) | a = 1.14b = –2.42 |
Note: Mean values of volume of distribution (VT), standard error (SE) of VT, Akaike information criterion (AIC), K1 and linear regression values from correlations between VT estimated using the 1- or 2TCM (see the corresponding graphs in Supplemental Figure 1). N = 8.