Fig. 1.

Schematic representation of the p arm of a generic acrocentric chromosome with tentative localization of the satellite DNA clusters (p11), the 47S rDNA clusters, binding sites for cohesins, condensins, transcription factors (e.g., CTCF, Oct4, Myc) (p12), the β satellite clusters (p12 and p13), and of the TRF2 protein binding site (telomere). The chromosomal regions are depicted on the left hand side; the red arrow indicates the position of the breakpoint and the BAC clone that is either lost or disrupted in the Class I RTs. This figure is based on McStay [2016], Floutsakou et al. [2013], Jarmuz-Szymczak et al. [2014], van Sluis et al. [2019], and Ramos et al. [2019]. For further details, see text.