Summary statements

• Satisfaction with therapy for hypothyroidism is influenced by many additional patient-specific factors (e.g., adequate sleep, regular exercise, and weight management), in addition to their dose and type of TH therapy.

• Patient-directed knowledge translation research is needed to inform patients of the risks, benefits, and uncertainties related to the choice of thyroid hormone preparations, based on evidence available from published trials.

• Patients note the importance of open communication with their health care provider about their symptoms.