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. 2021 Feb 16;10(1):10–38. doi: 10.1159/000512970

Summary statements

• THs have effects that are exerted through TRs but through noncanonical pathways, such as effects on triglyceride levels and some cardiovascular functions.

• THs may also exert effects that occur through non-TRmediated pathways, such as modification of cancer growth.

• More research is needed examining the effects of THs that may operate by noncanonical and non-TR-mediated pathways (e.g., cancer progression).