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. 2021 Feb 16;10(1):10–38. doi: 10.1159/000512970

Summary statements

• Alterations in TH transporter expression in the CNS and/or pituitary may compromise proper feedback within the HPT axis and polymorphisms may affect thyroid function tests on LT4/LT3 replacement.

• Alterations in TH transporter expression in the CNS may affect brain function and polymorphisms may affect the neural response to LT4/LT3 replacement.