Overview of the radiomic workflow. The major steps in the radiomic workflow consist of lesion identification and localization, segmentation, feature extraction, and prediction model construction. In the short term, lesion detection and localization may be facilitated either by directing the algorithm using a bounding box approach by the radiologist or, alternatively, by the radiologist pointing at the lesion of interest using a cursor. However, in the long term, lesion identification may also be performed automatically by the algorithm. It should be noted that regardless of the degree of automation, these steps would be performed under the supervision of the expert radiologist, with the ability to make adjustments or modifications as needed.