Table 1.
Rates of Adult BER/BEP Phenotypes in Intact versus Pre-Pubertal Ovariectomy (P-OVX) Rats.
| Primary Definition (57–67%) |
Less Strict Definition (40–50%) |
More Strict Definition (71–83%) |
||||
|---|---|---|---|---|---|---|
| Groups | BER | BEP | BER | BEP | BER | BEP |
| Combined Sample (N = 79 Intact, 77 P-OVX) | ||||||
| Raw PF Values | ||||||
| Intact | 35% (28/79) |
8% (6/79) |
46% (36/79) |
10% (8/79) |
28% (22/79) |
6% (5/79) |
| P-OVX | 9% (7/77) |
40% (31/77) |
12% (9/77) |
47% (37/77) |
5% (4/77) |
31% (24/77) |
| Z Test of Proportions | 3.70 | 4.35 | 4.71 | 4.82 | 3.42 | 3.63 |
| p value | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 |
| P-OVX Odds Ratio (95% CI) |
0.18 (0.07–0.45) |
8.20 (3.17–21.18) |
0.16 (0.07–0.36) |
8.21 (3.48–19.34) |
0.14 (0.05–0.44) |
6.70 (2.40–18.70) |
| Weight-Standardized Values | ||||||
| Intact | 24% (19/79) |
11% (9/79) |
30% (24/79) |
18% (14/79) |
19% (15/79) |
8% (6/79) |
| P-OVX | 15% (12/77) |
23% (18/77) |
21% (16/77) |
32% (25/77) |
14% (11/77) |
22% (17/77) |
| Z Test of Proportions | 1.32 | 1.94 | 1.37 | 2.10 | 0.79 | 2.45 |
| p value | .19 | .05 | .17 | .04 | .79 | .01 |
| P-OVX Odds Ratio (95% CI) |
0.58 (0.26–1.30) |
2.37 (0.99–5.67) |
0.60 (0.29–1.25) |
2.23 (1.06–4.72) |
0.71 (0.30–1.66) |
3.45 (1.28–9.29) |
| Experiment #1 (N = 30 Intact, 29 P-OVX) | ||||||
| Raw PF Values | ||||||
| Intact | 33% (10/30) |
13% (4/30) |
37% (11/30) |
17% (5/30) |
33% (10/30) |
13% (4/30) |
| P-OVX | 7% (2/30) |
37% (11/30) |
13% (4/30) |
40% (12/30) |
3% (1/30) |
33% (10/30) |
| Z Test of Proportions | 2.58 | 2.09 | 2.09 | 2.01 | 3.00 | 1.83 |
| p value | <.001 | .04 | .04 | .04 | .003 | .06 |
| P-OVX Odds Ratio (95% CI) |
0.14 (0.03–0.72) |
3.76 (1.04–13.65) |
0.27 (0.07–0.97) |
3.16 (0.95–10.50) |
0.07 (0.01–0.58) |
3.25 (0.89–11.90) |
| Weight-Standardized Values | ||||||
| Intact | 27% (8/30) |
13% (4/30) |
30% (9/30) |
17% (5/30) |
23% (7/30) |
13% (4/30) |
| P-OVX | 20% (6/30) |
23% (7/30) |
23% (7/30) |
27% (8/30) |
20% (6/30) |
23% (7/30) |
| Z Test of Proportions | 0.61 | 1.00 | 0.58 | 0.94 | 0.31 | 1.00 |
| p value | .54 | .32 | .56 | .35 | .76 | .32 |
| P-OVX Odds Ratio (95% CI) |
0.69 (0.21–2.30) |
1.97 (0.51–7.64) |
0.71 (0.22–2.25) |
1.82 (0.52–6.38) |
0.82 (0.24–2.81) |
2.13 (0.55–8.19) |
| Experiment #2 (N = 20 Intact, 20 P-OVX) | ||||||
| Raw PF Values | ||||||
| Intact | 45% (9/20) |
0% (0/20) |
60% (12/20) |
5% (1/20) |
30% (6/20) |
0% (0/20) |
| P-OVX | 10% (2/20) |
45% (9/20) |
15% (3/20) |
60% (12/20) |
5% (1/20) |
40% (8/20) |
| Z Test of Proportions | 2.48 | 3.41 | 2.94 | 3.71 | 2.08 | 3.16 |
| p value | .01 | <.001 | .003 | .002 | .04 | .002 |
| P-OVX Odds Ratio (95% CI) |
0.14 (0.02–0.75) |
33.87 (1.80–636.91) |
0.12 (0.03–0.54) |
28.50 (3.15–257.45) |
0.12 (0.01–1.14) |
27.88 (1.48–526.14) |
| Weight-Standardized Values | ||||||
| Intact | 30% (6/20) |
10% (2/20) |
45% (9/20) |
20% (4/20) |
20% (4/20) |
0% (0/20) |
| P-OVX | 15% (3/20) |
35% (7/20) |
20% (2/20) |
50% (10/20) |
10% (2/20) |
35% (7/20) |
| Z Test of Proportions | 1.14 | 1.89 | 2.48 | 1.99 | 0.89 | 2.91 |
| p value | .25 | .05 | .01 | .04 | .37 | .004 |
| P-OVX Odds Ratio (95% CI) |
0.41 (0.09–1.95) |
4.85 (0.86–27.22) |
0.14 (0.02–0.75) |
4.00 (0.98–16.27) |
0.44 (0.07–2.76) |
22.78 (1.20–432.61) |
| Experiment #3 (N = 29 Intact, 28 P-OVX) | ||||||
| Raw PF Values | ||||||
| Intact | 31% (9/29) |
7% (2/29) |
45% (13/29) |
7% (2/29) |
21% (6/29) |
3% (1/29) |
| P-OVX | 11% (3/28) |
39% (11/28) |
14% (2/28) |
46% (13/28) |
7% (2/28) |
21% (6/28) |
| Z Test of Proportions | 1.88 | 2.91 | 3.23 | 3.39 | 1.47 | 2.07 |
| p value | .06 | .004 | .001 | <.001 | .14 | .04 |
| P-OVX Odds Ratio (95% CI) |
0.35 (0.08–1.41) |
5.70 (1.16–28.04) |
0.16 (0.03–0.77) |
6.73 (1.39–32.58) |
0.35 (0.06–1.86) |
6.21 (0.70–54.96) |
| Weight-Standardized Values | ||||||
| Intact | 17% (5/29) |
10% (3/29) |
21% (6/29) |
17% (5/29) |
14% (4/29) |
7% (2/29) |
| P-OVX | 11% (3/28) |
14% (4/28) |
25% (7/28) |
25% (7/28) |
11% (3/28) |
11% (3/28) |
| Z Test of Proportions | 0.71 | 0.45 | 0.39 | 0.72 | 0.35 | 0.51 |
| p value | .48 | .65 | .70 | .47 | .73 | .61 |
| P-OVX Odds Ratio (95% CI) |
0.58 (0.12–2.68) |
1.44 (0.29–7.13) |
1.28 (0.37–4.42) |
1.60 (0.44–5.80) |
0.75 (0.15–3.70) |
1.62 (0.25–10.51) |
Note. BER = binge eating resistant; BEP = binge eating prone; Intact = ovaries intact; Primary Definition = rats had to score in the lowest/highest tertile in 57–67% of feeding tests to be categorized as BER/BEP; Less Strict Definition = rats had to score in the lowest/highest tertile in 40–50% of the tests to be categorized as BER/BEP; More Strict Definition = rats had to score in the lowest/highest tertile in 71–83% of the feeding tests to be categorized as BER/BEP; PF = palatable food; 95% CI = 95% confidence interval. Significant and trend-level Z tests are bolded.