TABLE 1.

Rates of BRAF p.V600E substitution in preoperative thyroid nodule specimens with malignant/Bethesda VI cytology reported in the literature ⁷ , ⁸ , ⁹ , ¹⁰ , ¹¹ , ¹² , ¹³ , ¹⁴ , ¹⁵ , ¹⁶ , ¹⁷ , ¹⁸ , ¹⁹ , ²⁰ , ²¹ , ²² , ²³ , ²⁴ , ²⁵ , ²⁶ , ²⁷

Study	Year	Country	Method	Cases, No.	BRAF rate (%)
Hemalatha et al. 7	2018	India	Sanger sequencing	37	46
Cañadas‐Garre et al. 8	2012	Spain	PCR RFLP	12	50
Eszlinger et al. a , 9	2014	Denmark	Pyrosequencing	42	52
Krane et al. a , 10	2015	United States	Pyrosequencing	42	52
Park et al. 11	2013	South Korea	Real‐time PCR	35	60
Biron et al. 12	2018	Canada	Digital droplet PCR	15	60
Yeo et al. 13	2012	South Korea	Pyrosequencing	136	63
Eszlinger et al. a , 14	2015	Italy	Pyrosequencing	30	63
Danilovic et al. 15	2014	Brazil	Real‐time PCR	35	66
Johnson et al. 16	2014	United Kingdom	PCR melting curve	18	67
Diggans et al. 17	2015	United States	Real‐time PCR	172	69
Beaudenon et al. a , 18	2014	United States	PCR hybridization	28	68
Eszlinger et al. a , 19	2017	Germany	Pyrosequencing	32	72
Zhao et al. 20	2015	China	Sanger sequencing	119	74
Kloos et al. 21	2013	United States	Real‐time PCR	48	75
Bellevicine et al. a , 22	2020	Italy	Real‐time PCR	165	76
Beiša et al. 23	2016	Lithuania	Real‐time PCR	49	80
Lee et al. 24	2012	South Korea	MEMO sequencing	876	85
Kim et al. 25	2018	South Korea	Real‐time PCR	41	85
Zhang et al. 26	2015	China	Real‐time PCR	37	86
Chang et al. 27	2012	South Korea	PCR melting curve	67	90

Abbreviations: PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; MEMO, mutant enrichment with 3′‐modified oligonucleotide.

^aStudies evaluating BRAF, RAS, RET and PAX8 gene alterations.