Table 2.
The effect of rs3212855 on lung function and blood markers upon smoking
| rs3212855 AA | rs3212855 AC/CC | |
|---|---|---|
| n | 55 | 10 |
| Sex (% male) | 76.8 | 81.8 |
| Age | 40 ± 2.4 | 50 ± 6.4 |
| BMI | 24 ± 0.4 | 26 ± 0.9 |
| % Current smokers | 91.1 | 72.7 |
| Mean no. of cigarettes per day | 9.8 ± 1.0 | 8.1 ± 2.1 |
| Pack‐years | 18 ± 2.3 | 19.8 ± 4.6 |
| FVC (% predicted) | 110.2 ± 1.8 | 103.1 ± 3.5 |
| FEV1 (% predicted)*** | 103.9 ± 2.5 | 80.9 ± 6.2 |
| FEV1/FVC** | 0.95 ± 0.02 | 0.79 ± 0.06 |
| Blood leucocytes | 6.5 ± 0.2 | 7.0 ± 0.5 |
| Blood neutrophils | 3.4 ± 0.2 | 3.7 ± 0.3 |
| Blood eosinophils | 0.19 ± 0.02 | 0.24 ± 0.01 |
| Blood lymphocytes | 2.2 ± 0.09 | 2.2 ± 0.14 |
| Blood CRP* | 1.9 ± 0.37 | 3.0 ± 0.6 |
Blood markers were measured 24 h after smoking three cigarettes within 1 h. All data are expressed as mean ± SEM. Statistical significance was tested using a Wilcoxon signed‐rank test with Bonferroni correction.
*
P < 0.05; **P < 0.01; ***P < 0.001.
BMI, body mass index; CRP, C‐reactive protein; FEV1, forced expiratory volume in 1 s; FEV1/FVC, FEV1 divided by the FVC; FVC, forced vital capacity; n, number of subjects; rs3212855 AA, individuals homozygous for the major allele of the SNP rs3212855; rs3212855 AC/CC, individuals homozygous for the minor allele of rs3212855 as well as heterozygous individuals; SNP, single nucleotide polymorphism.