Fig. 2.

γδ T cells and IFN‐γ modulate the pathogenicity of liver‐derived parasites in ECM development. Graphical summary of adoptive transfer experiments showing that pathogenic role of γδ T cells in ECM is dependent on the liver stage of infection. In the presence of IFN‐γ producing γδ T cells, the parasite that egresses the liver is more virulent and induces the inflammatory cascade that leads to ECM development. By contrast, pRBCs collected from TCRδ^−/− mice are substantially less pathogenic than those from WT mice.