TABLE 2.
Pharmacokinetic parameters of patients with hemophilia A in the three concentrate brand groups
| PK parameters | Total (n = 79) | Advate® (n = 23) | Kogenate FS® (n = 28) | GreenMono™ (n = 28) | Statistics | P |
|---|---|---|---|---|---|---|
| t1/2 (h) | 10.25 (8.75,12.75) | 10.18 ± 2.55 | 12.24 ± 2.60 | 9.62 ± 2.44 | 8.24* | < 0.01 |
| IVR (IU/kg per IU/dL) | 1.66 (1.53, 1.98) | 1.55 (1.48, 1.74) | 1.97 (1.66, 2.23) | 1.61 (1.45, 1.85) | 3.54# | < 0.01 |
| CL (mL·kg−1·h−1) | 4.89 (3.93, 6.34) | 6.23 (4.55, 6.86) | 4.16 (2.93, 5.72) | 5.11 (4.39, 6.67) | 2.77# | < 0.01 |
*t‐test; #Kruskal–Wallis test. t1/2 for each of the three divided groups is shown as mean ± standard deviation, t1/2 of all patients is shown as median (lower quartile, upper quartile); IVR and CL are both shown as median (lower quartile, upper quartile). PK, pharmacokinetic; t1/2, half‐life time; IVR, in vivo recovery; CL, clearance.