TABLE 3.
Pharmacokinetic parameters of patients with hemophilia A who exhibit different blood types
| PK parameters | FVIII | Blood group O | Blood group non‐O | t | P |
|---|---|---|---|---|---|
| t1/2 (h) | Kogenate FS® | 10.29 ± 1.32 | 15.05 ± 1.76 | −7.253 | < 0.01 |
| Advate® | 8.35 ± 1.29 | 11.60 ± 2.40 | −3.641 | < 0.01 | |
| GreenMono™ | 8.67 ± 1.64 | 10.50 ± 2.51 | −2.099 | 0.03 | |
| IVR (IU/kg per IU/dL) | Kogenate FS® | 2.04 ± 0.62 | 2.43 ± 0.81 | −1.288 | 0.21 |
| Advate® | 1.58 ± 0.23 | 1.67 ± 0.27 | −0.850 | 0.41 | |
| GreenMono™ | 1.70 ± 0.34 | 1.69 ± 0.33 | 0.034 | 0.97 | |
| CL (mL·kg−1·h−1) | Kogenate FS® | 6.36 ± 2.01 | 4.51 ± 1.21 | 2.576 | 0.02 |
| Advate® | 10.94 ± 2.69 | 6.63 ± 2.01 | 4.171 | < 0.01 | |
| GreenMono™ | 9.66 ± 4.01 | 6.38 ± 3.62 | 2.580 | 0.02 |
PK, pharmacokinetic; t1/2, half‐life time; IVR, in vivo recovery; CL, clearance.