TABLE 1.

Main physiological actions of Lactoferrin

Physiological actions	Mechanisms
Iron‐binding protein	Iron absorption, transport and sequestration
Host defence	Activities against pathogens: antibacterial, antifungal, antiparasitic, antiviral Anti‐inflammatory and alarming Anti‐endotoxin Anticancer Inhibition of prion accumulation
Host activities	Brain development and neuroprotection: alleviating psychological stress Bone formation Gastrointestinal development Immune actions (innate and adaptive): enhancer and modulator Wound healing
Metabolic	Adipocytes differentiation Antioxidant: inhibiting lipid peroxidation Association with other proteins: osteopontin and others Decreasing vasoconstriction Enzymatic activities Glucose regulation (decreasing hyperglycemia) Gut microbiota modulation Transcriptional regulator
Miscellaneous	Compounds or metabolites carrier (mainly into brain) Vaccine adjuvant Possible sAD biomarker