Table 3.

Adverse drug events (ADEs) categorised as Class 2 (in OR_e descending order)

(a) Male cases
No.	ADEs	ORe	(95% CI)	ORp	(95% CI)	Female class
1	Urinary retention	3.34	(2.93–3.82)	0.79	(0.69–0.91)	1
2	Fall	2.29	(1.93–2.73)	1.04	(0.87–1.25)	2
3	Cardiac failure	2.17	(1.94–2.43)	1.07	(0.95–1.20)	1
4	Osteonecrosis of jaw	2.14	(1.83–2.52)	0.60	(0.50–0.73)	2
5	Gastrointestinal haemorrhage	2.14	(1.89–2.43)	0.77	(0.67–0.89)	2
6	Pneumonia aspiration	2.14	(1.81–2.52)	1.14	(0.96–1.35)	1
7	Melaena	2.08	(1.78–2.43)	0.91	(0.77–1.07)	2
8	Cerebral haemorrhage	1.88	(1.70–2.07)	0.89	(0.80–0.99)	2
9	Pleural effusion	1.81	(1.54–2.12)	1.00	(0.84–1.18)	2
10	Cerebral infarction	1.79	(1.62–1.97)	0.73	(0.65–0.82)	2
11	Delirium	1.70	(1.49–1.94)	1.01	(0.87–1.16)	2
12	Decreased appetite	1.55	(1.40–1.72)	1.07	(0.96–1.20)	1
13	Platelet count decreased	1.46	(1.37–1.56)	0.97	(0.90–1.04)	2
14	Depressed level of consciousness	1.40	(1.21–1.63)	1.06	(0.90–1.24)	2
15	Pneumonia	1.40	(1.30–1.51)	1.02	(0.94–1.11)	1
16	Lymphoproliferative disorder	1.40	(1.16–1.68)	0.11	(0.06–0.16)	2
17	Death	1.26	(1.10–1.43)	0.62	(0.53–0.73)	2
18	Hypertension	1.25	(1.05–1.50)	0.69	(0.56–0.85)	4
19	Renal impairment	1.17	(1.08–1.26)	1.02	(0.94–1.11)	1

(b) Female cases
No.	ADEs	ORe	(95% CI)	ORp	(95% CI)	Male class
1	Gastrointestinal haemorrhage	3.69	(3.15–4.33)	1.05	(0.90–1.22)	2
2	Melaena	3.22	(2.69–3.86)	0.93	(0.77–1.11)	2
3	Fall	3.05	(2.63–3.54)	0.88	(0.75–1.03)	2
4	Delirium	2.89	(2.47–3.38)	1.11	(0.94–1.29)	2
5	Cerebral haemorrhage	2.61	(2.31–2.97)	0.83	(0.72–0.95)	2
6	Blood creatinine increased	2.16	(1.71–2.73)	1.15	(0.90–1.47)	1
7	Osteonecrosis of jaw	2.16	(1.95–2.39)	0.71	(0.63–0.80)	2
8	Death	1.99	(1.69–2.34)	0.67	(0.55–0.81)	2
9	Cerebral infarction	1.91	(1.71–2.13)	0.63	(0.55–0.72)	2
10	Haemoglobin decreased	1.46	(1.24–1.72)	0.88	(0.73–1.07)	4
11	Lymphoproliferative disorder	1.42	(1.26–1.60)	0.10	(0.07–0.13)	2
12	Infection	1.26	(1.04–1.54)	0.50	(0.38–0.64)	4
13	Platelet count decreased	1.23	(1.15–1.32)	0.97	(0.90–1.06)	2
14	Lung disorder	1.21	(1.01–1.45)	1.06	(0.87–1.30)	1
15	Depressed level of consciousness	1.21	(1.07–1.37)	1.05	(0.91–1.20)	2
16	Pleural effusion	1.20	(1.02–1.43)	1.12	(0.93–1.35)	2
17	Shock	1.20	(1.09–1.32)	0.89	(0.80–1.00)	4
18	Dizziness	1.20	(1.06–1.35)	0.94	(0.82–1.07)	1
19	Stomatitis	1.19	(1.02–1.38)	1.01	(0.85–1.19)	4

Underlined ADEs are categorised in a separate Class in the other sex

OR_e adjusted odds ratio with elderly as a factor for the occurrence of ADEs, OR_p adjusted odds ratio with polypharmacy as a factor for the occurrence of ADEs, 95% CI 95% confidence interval of OR_e and OR_p, Female Class class in which ADEs common in females are categorised, Male Class class in which ADEs common in males are categorised