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. Author manuscript; available in PMC: 2021 Mar 22.
Published in final edited form as: Nat Med. 2019 Apr 1;25(4):679–689. doi: 10.1038/s41591-019-0406-6

Extended Data Figure 10: Validation of meta-analysis single species associations in three independent cohorts.

Extended Data Figure 10:

(a) Heatmap showing for the core set of CRC-associated species (see Fig. 1) the rank of the respective species within the associations of each study (tested by two-sided Wilcoxon test), including the three independent validation cohorts (see Table 1), compared to the rank in the meta-analysis (meta, tested by two-sided blocked Wilcoxon test) on the left. (b) Precision-recall curves for the different independent validation cohorts using the meta-analysis set of associated species at FDR 0.005 (n=94, top) and 1E-05 (n=29, bottom) as “true” set (tested by two-sided blocked Wilcoxon test, see Methods) and the naïve (uncorrected) within-cohort significance (tested by two-sided Wilcoxon test) as predictor (see Supplementary Figure X).