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. Author manuscript; available in PMC: 2021 Mar 22.
Published in final edited form as: Nat Med. 2019 Apr 1;25(4):679–689. doi: 10.1038/s41591-019-0406-6

Extended Data Figure 4: Microbial genera identified in meta-analysis to be associated with CRC.

Extended Data Figure 4:

(a) Meta-analysis significance of microbial genera, computed using univariate two-sided Wilcoxon test blocked for study and colonoscopy (n=574 independent observations) is given by bar height (FDR 0.005). Underneath, significance (FDR-corrected p-value computed from two-sided Wilcoxon test) and generalized fold changes (see Methods) within individual studies are displayed as heatmaps in gray and color, respectively (see keys). Genera are ordered by meta-analysis significance and direction of change. (b) For highly significant genera (meta-analysis FDR 1E-05), association strength is quantified by the area under the Receiver Operating Characteristics (AUROC) across individual studies (color-coded diamonds) and 95% confidence interval are depicted by gray lines.