Table 1. Fecal metagenomic studies of colorectal cancer included in this meta-analysis.

See Methods for inclusion criteria and Supplementary Table S2 for extended meta-data. For a detailed description of patient recruitment and data generation for the DE study, see Methods. The data for 38 samples from the DE study had been published previously as part of an independent validation cohort in [8].

Country Code	Reference	No. of cases	No. of controls
FR	Zeller et al., 2014 [8]	53	61
AT	Feng et al., 2015 [9]	46	63
CN	Yu et al., 2017 [11]	74	54
US	Vogtmann et al., 2016 [10]	52	52
DE	this study	60	60
External validation cohorts
IT1	[27]	29	24
IT2	[27]	32	28
JP	Courtesy of T. Yamada et al.	40	40