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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Jun 26;1867(10):118786. doi: 10.1016/j.bbamcr.2020.118786

Figure 2. Identification of JAK and Src as regulators of the Nav1.6 complex by HTS.

Figure 2.

JAK and Src kinase inhibitors were consistently ranked among the highest scoring non-toxic compounds from an HTS of kinase inhibitors against the FGF14:Nav1.6 complex. Dose response plots are shown using screening library compound for the top eight inhibitors targeting JAK2 (orange) or Src (teal). Each compound’s structure is inlaid into its respective plot, demonstrating structural diversity among hits. Data are mean percent luminescence ± SD (n = 4 per treatment over two 384-well plates) with a non-linear regression curve fitting.