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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Jun 26;1867(10):118786. doi: 10.1016/j.bbamcr.2020.118786

Figure 8. Inhibition of JAK2 increases hippocampal CA1 pyramidal neuron firing in an FGF14-dependent manner.

Figure 8.

(A) Representative traces of maximal evoked action potentials in response to current injection in CA1 pyramidal neurons of Fgf14+/+ and Fgf14−/− mice following 1 hr incubation of coronal brain slices in DMSO (0.02%) or Fedratinib (20 μM). (B) Input-output curves of average number of evoked action potentials recorded in CA1 pyramidal neurons from Fgf14+/+ (left) or Fgf14−/− (right) mice in response to varying injected current stimuli. (C) Maximum number of action potentials fired from CA1 pyramidal neurons. (D) Resting membrane potential (RMP) (E) Current threshold (IThr) and (F) voltage threshold (VThr) for action potential firing in response to injected current in CA1 pyramidal neurons. Data in B-F are mean ± SEM. Statistical significance between groups was assessed using Student’s t-test with Welch Correction; *, p<0.05.