TABLE 2.
Post Hoc Pairwise Comparisons (Tukey HSD) of Scores at Each Time Point Between Recipients of Autologous and Allogeneic BMT and Healthy Controlsa
| Autologous BMT Versus Healthy Control |
Allogeneic BMT Versus Healthy Control |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Time Point | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 |
| NIS subscale | ||||||||||
| Critical Items | 9.34 | 8.47 | 7.51 | 7.01 | 5.60 | 8.26 | 7.62 | 6.23 | 9.87 | 10.83 |
| 95% CI | 12.5/6.1 | 12.1/4.8 | 11.3/3.8 | 10.9/3.1 | 9.7/1.5 | 11.4/5.1 | 11.0/4.3 | 9.6/2.9 | 13.3/6.5 | 14.6/7.0 |
| P | <.001 | <.001 | <.001 | <.001 | .004 | <.001 | <.001 | <.001 | <.001 | <.001 |
| Cognitive Efficiency | 10.2 | 10.1 | 7.36 | 6.20 | 7.63 | 9.06 | 8.33 | 8.17 | 8.79 | 10.08 |
| 95% CI | 13.9/6.5 | 14.6/5.1 | 11.6/3.2 | 10.9/1.5 | 12.3/2.9 | 12.8/5.4 | 12.4/4.3 | 11.9/4.4 | 12.9/4.7 | 14.5/5.7 |
| P | <.001 | <.001 | <.001 | .006 | .001 | <.001 | <.001 | <.001 | <.001 | <.001 |
| Attention | 6.03 | 6.82 | 5.91 | 4.47 | 5.87 | 5.46 | 3.14 | 4.85 | 6.47 | 7.51 |
| 95% CI | 10.1/2.0 | 11.5/2.1 | 10.6/1.2 | 9.6/−0.60 | 11.2/0.57 | 9.5/1.5 | 7.5/−1.2 | 9.0/0.67 | 10.9/2.0 | 12.4/2.6 |
| P | .002 | .002 | .009 | .097 | .026 | .004 | .20 | .018 | .002 | .001 |
| Memory | 4.54 | 6.45 | 6.06 | 3.86 | 6.05 | 5.05 | 2.79 | 4.51 | 6.56 | 8.71 |
| 95% CI | 8.4/0.71 | 10.7/2.1 | 10.3/1.8 | 8.8/−1.0 | 10.9/1.2 | 8.8/1.3 | 6.7/−1.1 | 8.3/0.71 | 10.9/2.3 | 13.2/4.2 |
| P | .015 | .001 | .003 | .15 | .01 | .005 | .22 | .015 | .001 | <.001 |
| Frustration Tolerance | 7.10 | 5.95 | 3.83 | 4.10 | 3.90 | 6.65 | 4.52 | 3.68 | 7.95 | 7.09 |
| 95% CI | 11.1/3.2 | 9.8/2.1 | 7.7/−0.04 | 8.5/−0.28 | 8.3/−0.48 | 10.2/3.1 | 8.1/0.95 | 7.2/0.22 | 11.8/4.1 | 11.2/3.0 |
| P | <.001 | .001 | .05 | .072 | .127 | <.001 | .009 | .034 | <.001 | <.001 |
| Learning-Verbal | 6.36 | 7.9 | 7.23 | 6.54 | 4.66 | 6.62 | 4.49 | 6.04 | 7.40 | 8.65 |
| 95% CI | 9.9/2.8 | 12.1/3.6 | 11.2/3.2 | 11.3/1.8 | 8.1/0.01 | 10.2/3.1 | 8.4/0.60 | 9.6/2.5 | 11.6/3.2 | 13.0/4.3 |
| P | <.001 | <.001 | <.001 | .004 | .049 | <.001 | .019 | <.001 | <.001 | <.001 |
| Academic Skills | 6.54 | 4.79 | 4.70 | 3.46 | 3.62 | 5.70 | 3.08 | 4.42 | 5.95 | 7.23 |
| 95% CI | 10.5/2.6 | 9.2/0.41 | 9.0/0.40 | 8.4/−1.5 | 8.5/−1.2 | 9.6/1.8 | 7.1/−0.95 | 8.3/0.57 | 10.3/1.6 | 11.7/2.7 |
| P | <.001 | .028 | .028 | .225 | .183 | .002 | .17 | .02 | .004 | .001 |
| GMI | 9.51 | 9.09 | 7.73 | 6.61 | 7.36 | 8.60 | 6.43 | 7.54 | 10.26 | 11.72 |
| 95% CI | 13.5/5.5 | 13.8/4.4 | 12.4/3.1 | 11.6/1.6 | 12.4/2.3 | 12.5/4.7 | 10.7/2.1 | 11.7/3.4 | 14.7/5.8 | 16.4/7.0 |
| P | <.001 | <.001 | <.001 | .006 | .002 | <.001 | .001 | <.001 | <.001 | <.001 |
Abbreviations: 0, before blood or bone marrow transplantation; 1, 6 months after blood or bone marrow transplantation; 2, 1 year after blood or bone marrow transplantation; 3, 2 years after blood or bone marrow transplantation; 4, 3 years after blood or bone marrow transplantation; BMT, blood or bone marrow transplantation; GMI, Global Measure of Impairment; HSD, honestly significant difference; NIS, Neuropsychological Impairment Scale.
Data are the estimate of the mean score difference. 95% CIs indicate upper bound/lower bound values. Bolded values indicate a P ≤ .003 significance level, adjusted for multiple comparisons. A positive value indicates greater self-endorsed cognitive problems on the NIS subscale in BMT recipients when compared with healthy controls.