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. 2020 Mar 26;53(4):995–1014. doi: 10.1002/jmri.27147

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© 2020 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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BCNU‐treated 9L rat glioma. Sodium MRI (top) and proton ADC maps (bottom) acquired at days 0, 7, and 23 (left to right) after BCNU injection, performed at the 17th day from tumor implantation. Central Na image at day 7 illustrates the main feature for all treated animals: A dramatic Na concentration increase observed throughout the entire tumor area. The images on day 23 show tumor during regrowth after tumor‐shrinking started at day 9 and its maximum regression on day 16. Reproduced from Ref. ⁵⁶ with permission from John Wiley & Sons, Magnetic Resonance in Medicine.