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Primary and secondary nucleation of Aβ oligomers. Adapted, with permission, from Liu et al., “Quaternary structure defines a large class of Aβ oligomers neutralized by sequestration” Cell Reports, 2015. Type 1 oligomers arise via primary nucleation. Type 2 oligomers arise via fibril‐catalyzed secondary nucleation. Both types of oligomers compete for a common pool of monomers
