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As a prodrug that releases a metal-binding agent, PcephPT consists of a β-lactam core (red) that is recognized by β-lactamase enzymes and a masked leaving group (blue) that prevents metal binding by the prochelator form. When cleaved, PcephPT releases the antimicrobial pyrithione (PT, blue), a bidentate metal-binding compound that forms a lipophilic 2:1 complex with Cu2+.
