FIGURE 1.

Case example of non‐invasive assessment with FFR_CT and FFR_CT planner and invasive assessment with ICA and FFR in a patient undergoing revascularization. Non‐invasive coronary computed tomography (CT) angiography showed diffuse disease in the RCA, with multiple severe stenoses along the course of the vessel. FFR_CT derived from standard coronary CT angiography images was calculated to be 0.57 in the distal RCA. Invasive assessment pre‐PCI confirmed diffuse disease in the mid and distal RCA with a corresponding FFR in the distal RCA of 0.66. Subsequently, PCI was performed with implantation of three stents with a total stent length of 81 mm, resulting in a post‐PCI FFR of 1.00. For computation of FFR_CT planner, the location of invasive FFR measurement and actual stent location were annotated in a computational model by a researcher blinded to invasive data. After simulation of stenosis removal, FFR_CT planner value was shown to 0.93. FFR, fractional flow reserve; FFR_CT, computed tomography derived FFR; ICA, invasive coronary angiography; PCI, percutaneous coronary intervention [Color figure can be viewed at wileyonlinelibrary.com]