Case example illustrating the use of the FFRCT planner tool in a patient with serial stenoses. FFRCT models of coronary CTA and ICA showed serial lesions in the proximal, mid, and distal LAD (stenosis labeled by white circles). FFRCT analysis showed comparable delta FFRCT for the proximal (0.07), mid (0.11), and distal (0.08) lesions, with an FFRCT in the distal LAD of 0.70. Invasive FFR pre‐PCI was shown to be 0.76 and since the distal lesions was angiographically most severe, the operator chose to treat the distal LAD. After PCI (stent labeled by white doted line), there was little increase in FFR (delta FFR of 0.01), with a post‐PCI FFR of 0.77. FFRCT planner analysis (stenosis modification labeled by white doted line) showed comparable results with a delta FFRCT of 0.01 and a FFRCT planner value of 0.71, demonstrating the usefullness of FFRCT planner in treatment planning of serial lesions. FFR, fractional flow reserve; FFRCT, computed tomography derived FFR; ICA, invasive coronary angiography; PCI, percutaneous coronary intervention [Color figure can be viewed at wileyonlinelibrary.com]