Table 3.
Iohexol Pharmacokinetics in Plasma
| Arithmetic Mean (CV%) | ||
|---|---|---|
| Pharmacokinetic Parameter | Metformin (n = 17) | Metformin + Tucatinib (n = 17) |
| AUC0‐last (µg·h/mL) | 345.5 (21.2) | 346.4 (21.7) |
| AUC0‐inf (µg·h/mL) | 440.5 (27.9) | 441.9 (27.2) |
| CLsyst (mL/min) | 129.8 (22.7) | 129.0 (22.0) |
| t½ (h) | 1.762 (18.9) | 1.784 (17.5) |
| C0 (µg/mL) | 175.6 (18.0) | 178.5 (21.5) |
| GFR (mL/min/1.73 m2) | 94.99 (17.4) | 94.56 (16.9) |
AUC0‐inf, area under the plasma concentration–time curve from time 0 to infinity; AUC0‐last, area under the plasma concentration‐time curve from time 0 to the last available measurement; C0, initial concentration; CLsyst, systemic clearance; CV, coefficient of variation; GFR, glomerular filtration rate; t½, terminal elimination half‐life.