Table 7.
Summary of selected microscopic findings in chickens for fattening fed the final combination of lasalocid A sodium and nicarbazin1
| Control | 1x | 1.5x | 2x | 3x | |
|---|---|---|---|---|---|
| Brain | |||||
| Brainstem, white matter, vacuolation | 0 | 0 | 0 | 0 | 3 |
| Cerebellum, white matter, vacuolation | 1 | 3 | 4 | 3 | 4 |
| Cerebrum, white matter, vacuolation | 0 | 0 | 3 | 5 | 6 |
| Midbrain, white matter, vacuolation | 0 | 4 | 8 | 8 | 8 |
| Minimal to mild | – | 4 | 5 | 1 | 1 |
| Moderate to severe | – | – | 3 | 7 | 7 |
| Spinal cord, thoracic | |||||
| White matter, vacuolation | 0 | 1 | 0 | 5 | 5 |
| Optic nerves, vacuolation | 0 | 2 | 4 | 4 | 8 |
| Minimal | – | 2 | 4 | 3 | 5 |
| Mild to moderate | – | – | – | 1 | 3 |
| Eyes, retina, ganglion cells decreased | |||||
| Bilateral, minimal to marked | 0 | 0 | 0 | 0 | 6 |
| Unilateral, minimal | 0 | 0 | 0 | 1 | 0 |
1
8 male birds per group sacrificed at day 40.