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. 2020 Oct 18;109(3):762–771. doi: 10.1002/cpt.2056

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© 2020 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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In vitro rosuvastatin transport in HEK293 cells. (a) Concentration dependent uptake of rosuvastatin in HEK293 cells overexpressing OATP1B1, (b) OATP1B3, (c) OATP2B1 (d), and NTCP, respectively. (e) Kinetic parameters of rosuvastatin uptake and transporter protein concentrations in HEK293‐transfected cells. (f) Predicted hepatic uptake clearance of rosuvastatin, obtained from clearance estimates in HEK293 cells and transporter concentrations in cells and liver biopsies in the 54 patients undergoing gastric bypass or cholecystectomy surgery. K_m, Michaelis‐Menten constant; V_max, maximal rate of transport. [Colour figure can be viewed at wileyonlinelibrary.com]