. 2021 Jan 21;22(3):35–47. doi: 10.1002/acm2.13172

TABLE 1.

Comparisons of plan parameters for prostate cancer patients for plans generated with SO and VOLO™.

	SO		VOLO™		SO‐VOLO™ ^a		P‐value ^b
	Mean	Range	Mean	Range	Mean [%]	Range [%]	P‐value ^b
PTV
D_98% [Gy]	35.2	[33.4, 37.3]	35.1	[32.6, 36.2]	0.3	[−4.9, 4.7]	0.5
D_0.03cc [Gy]	62.2	[54.3, 72.8]	61.3	[59.1, 67.7]	0.9	[−11.4, 16.5]	0.4
CI	1.2	[1.1, 1.4]	1.2	[1.1, 1.3]	−2.1	[−12.2, 11.0]	0.1
Rectum
D_0.03cc [Gy]	37.7	[35.2, 43.0]	36.2	[34.1, 41.6]	3.9	[−3.3, 15.4]	<0.001
D_1cc [Gy]	31.6	[27.5, 36.6]	30.0	[26.4, 33.3]	4.7	[−2.3, 20.5]	<0.001
D_mean [Gy]	11.6	[9.3, 15.9]	7.6	[5.3, 9.8]	34.3	[20.9, 45.8]	<0.001
V_40GyEq [%]	9.5	[4.2, 15.9]	6.0	[3.2, 10.7]	34.5	[−6.1, 66.5]	<0.001
V_60GyEq [%]	3.5	[1.5, 6.6]	2.4	[1.1, 4.0]	27.7	[−21.0, 71.9]	<0.001
Rectal Mucosa
D_0.03cc [Gy]	29.0	[26.8, 34.0]	25.7	[23.3, 27.6]	11.0	[0.0, 31.5]	<0.001
Bladder
D_0.03cc [Gy]	42.2	[39.0, 51.7]	40.8	[38.7, 46.9]	3.1	[−14.1, 16.9]	0.01
D_1cc [Gy]	38.7	[34.6, 44.5]	36.9	[34.1, 42.7]	4.7	[−7.6, 12.1]	<0.001
D_mean [Gy]	12.3	[8.1, 17.3]	9.3	[7.1, 12.3]	23.5	[−10.0, 41.0]	<0.001
Urethra
D_5% [Gy]	43.1	[39.7, 50.9]	41.4	[39.5, 45.4]	3.8	[−3.9, 14.9]	0.001
D_10% [Gy]	42.3	[39.4, 49.9]	41.0	[39.1, 45.1]	3.0	[−3.8, 14.0]	0.002
D_50% [Gy]	40.0	[36.6, 46.3]	39.7	[38.0, 43.8]	0.7	[−4.6, 10.6]	0.4
Body
V_5Gy [cc]	2576.4	[1754.3, 3565.8]	2342.7	[1687.4, 2980.4]	8.0	[−30.1, 18.3]	<0.001
V_10Gy [cc]	871.9	[436.2, 1721.6]	938.8	[632.7, 1218.8]	−13.6	[−67.2, 29.7]	0.04
V_20Gy [cc]	207.1	[118.9, 359.7]	217.2	[138.4, 295.0]	−6.5	[−26.4, 18.0]	0.01
V_30Gy [cc]	110.6	[64.7, 176.4]	114.1	[73.6, 158.1]	−4.2	[−13.8, 10.3]	0.01
Plan Parameters
MU	47377	[33598, 60794]	23524	[19873, 35512]	48.7	[6.9, 66.4]	<0.001
WSS [mm²]	451.0	[320.4, 660.0]	873.0	[560.6, 1248.5]	−97.5	[−161.2, −10.5]	<0.001
MCS	0.49	[0.31, 0.61]	0.50	[0.33, 0.60]	−5.9	[−51.3, 27.3]	0.2
NoF Beams	73.9	[51,115]	47.4	[37,59]	26.5	[6.0, 57.0]	<0.001
NoF Nodes	60.9	[46,90]	47.4	[37,59]	13.4	[−2.0, 42.0]	<0.001
NoF Segments	107.2	[54,235]	92.9	[54,167]	8.9	[−72.5, 62.1]	0.06
Estimated Delivery Time [min]	29.5	[20.1, 38.3]	21.5	[16.6, 31.6]	26.7	[−3.6, 42.5]	<0.001

^{^a}

percentage values are given as: (SO‐VOLO™)*100/SO.

^{^b}

Bold P‐values represent statistically significant results (P < 0.05).