. 2021 Jan 21;22(3):35–47. doi: 10.1002/acm2.13172

TABLE 2.

Comparisons of plan parameters for lung cancer patients for plans generated with SO and VOLO™.

	SO		VOLO™		SO‐VOLO™ ^a
	Mean	Range	Mean	Range	Mean [%]	Range [%]	P‐value ^b
PTV
D_98% [Gy]	55.0	[54.9, 55.1]	55.0	[54.9, 55.1]	0.0	[−0.2, 0.2]	0.3
D_0.03cc [Gy]	71.9	[67.3, 91.1]	73.2	[69.0, 89.6]	‐1.9	[−5.9, 1.7]	0.001
CI	1.2	[1.1, 1.8]	1.2	[1.1, 1.8]	0.6	[−14.4, 13.4]	0.5
Esophagus
D_0.03cc [Gy]	15.4	[2.8, 35.0]	12.5	[1.5, 30.5]	18.9	[−4.4, 70.9]	<0.001
D_mean [Gy]	3.8	[0.7, 10.8]	3.3	[0.4, 9.4]	13.4	[−38.8, 62.8]	0.002
Main Bronchus
D_0.03cc [Gy]	20.1	[0.5, 50.0]	18.1	[0.4, 44.7]	11.1	[−101.5, 57.6]	0.003
D_mean [Gy]	6.2	[0.2, 18.1]	5.8	[0.2, 15.1]	7.6	[−42.6, 50.4]	0.1
Skin
D_0.03cc [Gy]	12.6	[6.6, 18.9]	12.5	[7.0, 18.3]	‐1.9	[−52.3, 24.5]	0.7
D_mean [Gy]	0.5	[0.2, 0.9]	0.4	[0.2, 0.9]	2.8	[−2.9, 8.4]	0.002
Spinal Cord
D_0.03cc [Gy]	11.8	[1.1, 25.1]	10.4	[0.9, 22.7]	13.2	[−48.6, 65.9]	0.01
D_mean [Gy]	2.2	[0.4, 4.7]	2.0	[0.2, 4.4]	11.2	[−32.9, 70.1]	0.02
Thoracic Wall
D_30cc [Gy]	18.1	[7.3, 35.9]	17.0	[8.3, 29.9]	4.4	[−13.7, 18.0]	0.008
D_mean [Gy]	4.8	[1.3, 14.0]	4.6	[1.4, 12.7]	2.7	[−12.5, 16.8]	0.01
Trachea
D_0.03cc [Gy]	9.9	[0.3, 41.3]	8.5	[0.2, 37.3]	16.1	[−23.1, 45.5]	0.001
D_mean [Gy]	2.4	[0.1, 8.8]	2.2	[0.1, 9.9]	11.9	[−16.1, 47.0]	0.08
Lung
V_5Gy [%]	18.8	[3.3, 37.5]	18.7	[3.6, 38.5]	0.5	[−22.4, 12.8]	0.6
V_16Gy [%]	5.6	[0.8, 11.4]	5.6	[0.8, 12.1]	‐1.7	[−19.8, 14.9]	0.5
V_20Gy [%]	4.1	[0.6, 8.3]	4.1	[0.6, 8.5]	‐1.8	[−21.0, 13.9]	0.6
V_30Gy [%]	2.3	[0.4, 4.7]	2.3	[0.4, 4.7]	‐1.4	[−20.5, 9.5]	0.6
Body
V_5Gy [cc]	7.1	[2.0, 13.6]	6.9	[1.9, 13.5]	3.8	[−8.1, 19.2]	0.006
V_10Gy [cc]	2.8	[0.6, 7.3]	2.8	[0.8, 6.9]	0.4	[−16.9, 20.8]	0.1
V_20Gy [cc]	0.8	[0.2, 2.9]	0.8	[0.2, 2.8]	2.5	[−17.9, 20.8]	0.09
V_30Gy [cc]	0.4	[0.1, 1.4]	0.4	[0.1, 1.4]	0.8	[−15.9, 17.1]	0.5
Plan Parameters
MU	29265	[19111, 40147]	19584	[14143, 33648]	32.8	[5.3, 51.4]	<0.001
WSS [mm²]	532.6	[273.8, 1198.1]	864.3	[349.0, 2096.6]	‐58.4	[−116.2, −7.4]	<0.001
MCS	0.43	[0.33, 0.53]	0.53	[0.45, 0.65]	‐24.6	[−74.4, 10.8]	<0.001
NoF Beams	45.5	[34,63]	41.3	[32,61]	7.9	[−61.8, 31.0]	0.003
NoF Nodes	45.5	[34,63]	41.3	[32,61]	7.9	[−61.8, 31.0]	0.003
NoF Segments	74.3	[47,115]	66.1	[41,121]	10.5	[−75.9, 45.7]	0.02
Estimated Delivery Time [min]	25.4	[18.1, 34.5]	21.6	[15.6, 33.5]	14.5	[−30.2, 40.5]	<0.001

^{^a}

percentage values are given as: (SO‐VOLO™)*100/SO.

^{^b}

Bold P‐values represent statistically significant results (P < 0.05).