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. 2021 Mar 17;41(11):2496–2511. doi: 10.1523/JNEUROSCI.1985-20.2020

Table 10.

Summary of main findings for group comparisons, classifications, and brain-behavior associationsa

Non-AP vs Non-mus AP vs Non-mus AP vs Non-AP
Functional connectivity of auditory ROIs Non-AP musicians show increased interhemispheric functional connectivity between the left and right PT AP musicians show increased interhemispheric functional connectivity between the left and right auditory cortex (PT and HG), and between bilateral auditory cortex and right inferior frontal regions No statistical evidence for group differences
Associations between functional connectivity of auditory ROIs and behavior Positive association between tone-naming proficiency and functional connectivity of the right HG and associative auditory areas within musicians; negative association between age of onset and functional connectivity between right PT and right DLPFC within musicians
Functional network topology Non-AP musicians show higher average strength and cluster coefficient, and a lower global efficiency AP musicians show higher average strength and cluster coefficient, and a lower global efficiency No statistical evidence for group differences
Functional subnetworks Non-AP musicians show increased functional connectivity within subnetwork consisting of bilateral auditory cortex, bilateral inferior frontal cortex, anterior and middle temporal cortex, and inferior parietal cortex AP musicians show increased functional connectivity within subnetwork consisting of bilateral auditory cortex, right inferior frontal cortex, left anterior temporal cortex, and inferior parietal cortex No statistical evidence for group differences
Functional network-based classification Statistically significant classification No statistical evidence for successful classification
Structural connectivity of auditory ROIs Non-AP musicians show increased MD in transcallosal white-matter tract connecting left and right PT AP musicians descriptively show a trend toward increased MD in transcallosal white-matter tract connecting left and right PT No statistical evidence for group differences
Association between structural connectivity of auditory ROIs and behavior Negative association between age of onset of musical training and FA values and positive association with MD values of white-matter tract between left and right PT within musician groups
Structural network topology No statistical evidence for group differences No statistical evidence for group differences No statistical evidence for group differences
Association between structural network topology and behavior Positive association between age of onset and betweenness centrality in musicians
Structural subnetworks Non-AP musicians show increased structural connectivity within a subnetwork consisting of right-hemispheric sensorimotor (preCG, postCG), medial temporal, and frontal cortex as well as bilateral perisylvian regions AP musicians show increased structural connectivity within a subnetwork consisting of right-hemispheric sensorimotor (preCG, postCG), inferior temporal, and frontal cortex, as well as bilateral insular cortex and bilateral perisylvian regions No statistical evidence for group differences
Structural network-based classification No statistical evidence for successful classification No statistical evidence for successful classification

aNon-mus, Non-musicians.