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. Author manuscript; available in PMC: 2021 Mar 22.
Published in final edited form as: Biochem J. 2020 Jul 17;477(13):2421–2438. doi: 10.1042/BCJ20200036

Figure 3. Runx1 deficiency in chondrocytes and osteoblasts leads to a decrease in the expression of chondrocyte hypertrophic related genes.

Figure 3.

Immunohistochemistry (IHC) staining of chondrocyte differentiation marker genes in the femurs of 3-week old Runx1f/fCol2α1-cre and Runx1f/f mice, including anti-Runx1 (A), anti-Runx2 (B), anti-PCNA (C), anti-Col2α1 (D), anti-Col10α1 (E), and anti-MMP13 (F). (G) Quantification of positive staining cells and area in (A)-(F). All data are presented as mean ± SD, n=6, NS denotes not significant, **p<0.01, ***p<0.001.