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. 2021 Mar 10;17(3):e1009375. doi: 10.1371/journal.ppat.1009375

Fig 1. LasR deficient variants induce increased levels of mICAM-1 in AEC.

Fig 1

BEAS-2B cells were stimulated for 24h with 30 μL sterile filtrates of (A) the Early clinical isolate and its isogenic lasR mutant, (B) five “early” clinical isolates or PA14 wild-type and their isogenic lasR mutants or (C) three “early” clinical isolates paired with their clonally-related “late” isolates (Early/Late, E6/L6, E7/L7). mICAM-1 levels (MFI) were measured by flow cytometry, with SCFM (media) serving as negative control (—dashed line). Results are shown as the mean ± SD of one representative experiment (from ≥ 2 independent experiments, each with biological triplicates). *P < 0.05; **P < 0.01; ***P < 0.001.