Table 1. Estimated parameters (fixed effect) for SARS-CoV-2, MERS-CoV, and SARS-CoV infection.
| Parameter name | Symbol (unit) | SARS-CoV-2 | MERS-CoV | SARS-CoV |
|---|---|---|---|---|
| Parameters in the model | ||||
| Maximum rate constant for viral replication | γ (day−1) | 4 | 1.46# | 4.13 |
| Rate constant for virus infection | β ((copies/ml)−1 day−1) | 5.2×10−6 | 1.4×10−8# | 4.9×10−8# |
| Death rate of infected cells | δ (day−1)& | 0.93 | 0.93 | 0.93 |
| Viral load at symptom onset | V(0) (copies/ml) | 6.5×103 | 6.6×104 | 3.3×10−2# |
| Quantities derived from the parameters | ||||
| Mean duration of virus production | L (days) | 1.08 | 1.08 | 1.08 |
| Within-host reproduction number at symptom onset | RS0 | 4.30 | 1.57# | 4.44 |
| Critical inhibition level | C* | 0.77 | 0.38# | 0.75 |
| Time from symptom onset to viral load peak | Tp (days)$ | 2.0 | 12.2 | 7.2$ |
#Statistically different from SARS-CoV-2 (the Wald test).
&The death rate of infected cells was assumed to be the same between the viruses in the process of model selection.
$Tp was computed from simulation, and the difference from SARS-CoV-2 was tested by the jackknife test.