. 2021 Mar 4;37(2):90–96. doi: 10.1089/jop.2020.0085

Table 2.

Clinical Parameters at Baseline and After 7 and 28 Days of Treatment

	Baseline	95% CI	Day 7	95% CI	Day 28	95% CI
Burning	2 ± 0.8	1.75–2.25	1.9 ± 0.8	1.69–2.21	1.2 ± 0.8^a,b	1.0–1.49
Ocular dryness	2.2 ± 0.8	1.95–2.44	2 ± 0.8	1.79–2.31	1.6 ± 0.8^c,d	1.28–1.76
Foreign body sensation	1.8 ± 0.4	1.67–1.93	1.7 ± 0.6	1.57–1.92	1.1 ± 0.8^e,f	0.89–1.41
Watery eyes	0.7 ± 1.0	0.42–1.07	0.7 ± 1.0	0.42–1.07	0.4 ± 0.8^g	0.16–0.63
Tearing	0.1 ± 0.3	0.00–0.19	0.1 ± 0.3	0.00–0.19	0.1 ± 0.3	0.00–0.19
Photophobia	0.5 ± 0.8	0.25–0.75	0.5 ± 0.8	0.25–0.75	0.4 ± 0.3	0.18–0.65
Ocular pain	0.1 ± 0.3	0.00–0.19	0.1 ± 0.3	0.00–0.19	0.1 ± 0.3	−0.01–0.16
OSDI	19.4 ± 7.5	16.70–21.95	19.6 ± 7	17.30–21.97	18.8 ± 6.1	16.36–21.19
TBUT	2.2 ± 0.7	1.92–2.40	2.65 ± 1.3^h	2.07–3.02	4 ± 1.5^i,j	3.42–4.47
Ocular surface staining	3.3 ± 0.5	3.15–3.44	3.3 ± 0.4	3.15–3.44	1.6 ± 0.9^k,l	1.25–1.85
Schirmer I	4.8 ± 4.5	3.18–6.19			4.6 ± 4.1	3.17–6.19
Endothelial cell density	2746.7 ± 306.6	2506.5–2851.2			2789.8 ± 297.5	2551.3–2884.8
Intraocular pressure	15.4 ± 2.1	13.9–16.2			14.9 ± 2.2	13.4–15.7

Data are presented as mean ± standard deviation.

^{^a}

P = 0.0002 (vs. baseline).

^{^b}

P = 0.0005 (vs. day 7).

^{^c}

P = 0.0003 (vs. baseline).

^{^d}

P = 0.006 (vs. day 7).

^{^e}

P = 0.0001 (vs. baseline).

^{^f}

P = 0.0003 (vs. day 7).

^{^g}

P = 0.03 (vs. baseline).

^{^h}

P = 0.0008 (vs. baseline).

^ⁱ

P < 0.0001 (vs. baseline).

^{^j}

P < 0.0001 (vs. day 7).

^{^k}

P < 0.0001 (vs. baseline).

^{^l}

P < 0.0001 (vs. day 7).

CI, confidence interval; OSDI, ocular surface disease index; TBUT, tear film break-up time.