Table 1.
RA |
IH |
|||||||
---|---|---|---|---|---|---|---|---|
Topical ocular |
Oral |
Topical ocular |
Oral |
|||||
Saline | Prop | Saline | Prop | Saline | Prop | Saline | Prop | |
% Change body wt. (P0–P14) | 252.6 ± 14.9 | 208.8 ± 14.9** | 286.2 ± 7.8# | 258.9 ± 14.8# | 252.0 ± 18.8 | 159.3 ± 18.2**# | 214.5 ± 18.2§§ | 244.9 ± 10.8##§§ |
% Change length (P0–P14) | 57.1 ± 2.1 | 35.7 ± 8.5** | 54.6 ± 2.7 | 53.5 ± 2.4## | 55.5 ± 6.6 | 36.3 ± 3.7** | 55.4 ± 2.6 | 61.1 ± 2.4##§ |
Brain/body wt. ratio | 0.046 ± 0.002 | 0.049 ± 0.0016 | 0.047 ± 0.001 | 0.044 ± 0.006 | 0.044 ± 0.001 | 0.05 ± 0.004 | 0.049 ± 0.003 | 0.044 ± 0.001 |
Heart/body wt. ratio | 0.006 ± 0.0003 | 0.006 ± 0.0005 | 0.007 ± 0.0003 | 0.007 ± 0.007 | 0.007 ± 0.0003 | 0.007 ± 0.0007 | 0.007 ± 0.0005 | 0.006 ± 0.0003 |
Lung/body wt. ratio | 0.018 ± 0.0009 | 0.018 ± 0.0009 | 0.018 ± 0.0001 | 0.02 ± 0.001** | 0.018 ± 0.0007 | 0.024 ± 0.001** | 0.018 ± 0.001 | 0.019 ± 0.001##§§ |
Liver/body wt. ratio | 0.028 ± 0.001 | 0.027 ± 0.002 | 0.027 ± 0.0009 | 0.028 ± 0.003 | 0.028 ± 0.002 | 0.028 ± 0.002 | 0.03 ± 0.002 | 0.03 ± 0.001 |
Kidney/body wt. ratio | 0.013 ± 0.0005 | 0.013 ± 0.0007 | 0.014 ± 0.0007 | 0.014 ± 0.001 | 0.014 ± 0.0005 | 0.014 ± 0.001 | 0.015 ± 0.0004 | 0.014 ± 0.0005 |
P < 0.05, **P < 0.01 saline versus propranolol; #P < 0.05, ##P < 0.01 topical ocular versus oral; §P < 0.05, §§P < 0.01 RA versus IH (n = 18 pups/group).
IH, intermittent hypoxia; Prop, propranolol; RA, room air; Wt., weight.