Criteria for tumor progression in HERBY (adapted from the RANO criteria)

Parameter	Criterion
T1-weighted post-Gd measurable disease	≥25% increase in the sum of the products of perpendicular diameters of the contrast-enhancing lesions compared with the smallest tumor measurement obtained either at baseline (if no decrease was observed) or best response with the patient on stable or increasing doses of corticosteroids
T1-weighted post-Gd nonmeasurable disease	Clear progression of nonmeasurable lesions
T2/FLAIR	Substantial increase in the T2/FLAIR nonenhancing lesion compared with the baseline scan or best response after the initiation of therapy with the patient on a stable or increasing dose of corticosteroids
	The increase in the T2/FLAIR signal must have occurred and not be the result of comorbid events (eg, radiation therapy, demyelination, ischemic injury, seizures, postoperative changes, or other treatment effects)
New lesions	Any new lesions
Clinical	Clear clinical deterioration due to tumor and not attributable to other causes (eg, seizures, medication adverse effects, complications of therapy, cerebrovascular events, infection, and so forth)
Failure to return	Failure to return for evaluation as a result of death or deteriorating condition

Note:—Gd indicates gadolinium.