Fig. 6.

PKD2 mRNA expression is upregulated and PKD1 mRNA expression is downregulated in urothelial bladder cancer tissues. a PKD1 mRNA expression was analyzed using the bladder cancer datasets from two independent clinical studies by Blaveri et al. [52] and Sanchez-Carbayo et al. [51], as described in “Materials and methods”. The mRNA expression levels of PKD1 are significantly decreased in the bladder tumor samples of both studies. P < 0.0001 for the tumor tissue groups vs. the normal tissue groups. b PKD2 mRNA expression was assessed using the bladder cancer datasets from two independent clinical studies by Dyrskjot et al. [50] and Sanchez-Carbayo et al. [51] downloaded from the Oncomine database. The mRNA expression levels of PKD2 are markedly increased in the bladder tumor samples of both studies. P < 0.0001 for the tumor tissue groups vs. the normal tissue groups