Table 2. Clinical characteristics, hospital management and outcomes of confirmed and probable cases of the two outbreaks.

Characteristics		Outbreak 1 Dec, 2017 –Apr, 2018		Outbreak 2 Aug, 2018 –Dec, 2018		P value
		n	%	n	%
Total		69	100.0	14	100.0
Case type	Confirmed	63	91.3	7	50.0	<0.001**
	Probable	6	8.7	7	50.0
Presenting symptoms
General	Fever	60	87.0	14	100.0	0.359**
	Fatigue	58	84.1	14	100.0	0.276**
	Respiratory distress	53	76.8	8	57.1	<0.001**
	Myalgia	47	68.1	9	64.3	0.022**
	Bleeding	32	46.4	12	85.7	0.026**
	Sore throat	32	46.4	11	78.6	0.010**
	Vomiting	32	46.4	11	78.6	0.095**
	Diarrhoea	32	46.4	8	57.1	0.660**
	Oedema	22	31.9	7	50.0	<0.001**
	Hypotension	21	30.4	5	35.7	0.013**
	Red eye*	20	29.0	11	78.6	<0.001**
Neurological	Altered consciousness	20	29.0	11	78.6	0.002**
	Seizure	18	26.1	13	92.9	<0.001**
	Neck pain	8	11.6	10	71.4	<0.001**
	Hearing Impairment	4	5.8	4	28.6	<0.001**
	Ear pain	1	1.4	10	71.4	<0.001**
	No Neuro symptoms	39	56.5	1	7.1	0.001**
	Any Neuro symptom	30	43.5	13	92.9
Treated	Yes	56	81.2	8	57.1	0.051**
	No	13	18.8	6	42.9
Outcome	Survived	47	68.1	2	14.3	<0.001**
	Died	20	29.0	12	85.7
	LAMA	2	2.9	0	0.0
Lab tests	Protein in urine	51	73.9	7	50.0	0.036**
	Blood in urine	52	75.4	8	57.1	0.295**
Creatinine (umol/l)	<53	4	5.8	0	0.0
	53–106	38	55.1	11	78.6	0.233**
	>106	27	39.1	3	21.4
Urea (mm/L)	<2.5	2	2.9	0	0.0
	2.5–7.9	54	78.3	11	78.6	0.800**
	>7.9	13	18.8	3	21.4
AST (mmol/l)	<11	1	1.5	0	0.0
	11–38	29	42.0	8	57.1	0.549**
	>38	39	56.5	6	42.9
ALT (mmol/l)	<10	6	8.7	0	0.0
	10–47	47	68.1	11	78.6	0.493**
	>47	16	23.2	3	21.4
Platelet count	<150	27	39.1	6	42.9	0.795**
	150–450	42	60.9	8	57.1
	Creatinine umol/LL [median (IQR)]	105 (73–153) N = 55		189 (84.5–293.5) N = 5		0.309***
	AST (IU/L) [median (IQR)]	54 (34–89) N = 55		8 (60–142) N = 6		0.118***
	Urine output mL/m2/24hrs [mean (SD)]	1.9 (2.1) N = 69		5.3 (3.9) N = 14		0.001*
	Platelet count x109/l [mean (SD)]	156.5 (82.0) N = 54		87.8 (23.6) N = 6		0.007*

* Red eyes, subconjunctival haemorrhage; LAMA: Left Against Medical Advice; IQR: interquartile range; AST, Aspartate aminotransaminase; Neuro: Neurological

* T-test

** Chi squared test

*** Kruskal Wallis test.