Figure 3.

Gating properties of steady-state activation and inactivation and window currents. (A) Voltage-dependence of steady-state activation and inactivation in wild type (• activation, n = 9; inactivation, n = 9); Q1491H (▪ activation, n = 9; inactivation, n = 7); and G1481V (▲; activation, n = 9; and inactivation, n = 7). The inactivated currents were generated using the protocol described in the insets, and the activated currents were obtained from the IV recording. The resulting data were fitted to a standard Boltzmann function. (B) The predicted window current was obtained using equation 1 (see Methods).