Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 5;3(3):256–266. doi: 10.1016/j.cjco.2020.09.023

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Canadian Cardiovascular Society. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Open state structure of the human Na_v1.5 sodium channel. (A) Top view of the cryogenic electron microscopy (Cryo-EM) structure of rat Na_v1.5 channel showing the IFM motif in red spheres. (B) Bottom view of the Cryo-EM structure of the rat Na_v1.5 channel showing the isoleucine, phenylalanine, and methionine (IFM) motif in red spheres. (C) Close-up view of the IFM motif flanked by G1481 on the N-terminal and Q1491 on the C-terminal. A strong hydrogen bond between N1661 and Q1491 (2.9A) ensures the proper docking of the IFM motif. DII, sodium channel domain 2; DIV, sodium channel domain 4.