Table 3.

Von Willebrand factor (VWF) activity, VWF antigen concentration, and ADAMTS13 activity in patients with nonvalvular atrial fibrillation who during follow-up had a thromboembolic event (panel A), major bleeding (panel B), or the composite of major bleeding and clinically relevant nonmajor bleeding (CRNMB, panel C), compared with those without these events

A. Thromboembolic event
Variable	Thromboembolic event (n = 32)	No thromboembolic event (n = 342)	P value
VWF activity			0.07
Mean (SD)	158.8 (46.2)	144.7 (51.8)
Median (min, max)	153.5 (96.4, 271.7)	135.0 (49.2, 375.2)
VWF antigen			0.017
Mean (SD)	180.5 (53.0)	157.7 (53.1)
Median (min, max)	184.0 (98.0, 298.0)	152.5 (49.0, 399.0)
ADAMTS13 activity			0.28
Mean (SD)	120.8 (35.2)	115.4 (46.9)
Median (min, max)	125.2 (53.7, 187.8)	106.1 (30.7, 289.3)

B. Major bleeding
Variable	Major bleeding (n = 21)	No major bleeding (n = 353)	P value
VWF activity			0.13
Mean (SD)	148.3 (39.6)	145.8 (52.1)
Median (min, max)	139.0 (85.2, 218.6)	136.1 (49.2, 375.2)
VWF antigen			0.65
Mean (SD)	162.5 (43.0)	159.5 (54.0)
Median (min, max)	158.0 (77.0, 259.0)	152.5 (49.0, 399.0)
ADAMTS13 activity			0.11
Mean (SD)	104.1 (50.5)	116.5 (45.7)
Median (min, max)	86.8 (44.7, 258.0)	110.7 (30.7, 289.3)

C. CRNMB
Variable	CRNMB (n = 25)	No CRNMB (n = 349)	P value
VWF activity			0.13
Mean (SD)	156.1 (41.4)	145.2 (52.1)
Median (min, max)	164.5 (85.2, 229.8)	135.6 (49.2, 375.2)
VWF antigen			0.19
Mean (SD)	169.3 (44.0)	158.9 (54.0)
Median (min, max)	162.0 (77.0, 259.0)	154.0 (49.0, 399.0)
ADAMTS13 activity			0.026
Mean (SD)	99.7 (47.7)	117.0 (45.7)
Median (min, max)	86.1 (44.7, 258.0)	111.0 (30.7, 289.3)

ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; SD, standard deviation.