Table 4.
Multivariate analysis of covariates modeled as a time to the first event, associated with the risk of thromboembolic events (subset A), major bleeding (subset B), composite of major and clinically relevant nonmajor bleeding (subset C), all-cause mortality (subset D), composite of thromboembolism and all-cause mortality (subset E), and the composite of major, clinically relevant nonmajor, and all-cause mortality (subset F)
| Variable | Hazard ratio | 95% CI | P value |
|---|---|---|---|
| A. Thromboembolic events (n = 32) | |||
| CHA2DS2-VASc score | 1.349 | (1.110, 1.639) | 0.003 |
| LAAT | 2.291 | (0.756, 6.940) | 0.143 |
| VWF antigen | 1.005 | (0.998, 1.011) | 0.170 |
| On anticoagulation for > 2 y | 0.777 | (0.303, 1.990) | 0.599 |
| B. Major bleeding (n = 21) | |||
| CHA2DS2-VASc score | 1.571 | (1.162, 2.123) | 0.003∗ |
| LAA emptying velocity ≤ 25 | 3.046 | (0.947, 9.798) | 0.062 |
| On anticoagulation for > 2 y | 2.695 | (0.297, 24.460) | 0.378 |
| C. Major or clinically relevant nonmajor bleeding (n = 32) | |||
| CHA2DS2-VASc score | 1.650 | (1.250, 2.177) | < 0.001 |
| On anticoagulation for > 2 y | 3.284 | (0.375, 28.776) | 0.283 |
| LAA emptying velocity ≤ 25 | 1.882 | (0.656, 5.402) | 0.240 |
| D. All-cause mortality (n = 18) | |||
| CHA2DS2-VASc score | 1.717 | (1.273, 2.315) | <0.001 |
| VWF antigen | 1.011 | (1.003, 1.020) | 0.011 |
| On anticoagulation for >2 y | 1.830 | (0.216, 15.465) | 0.579 |
| E. Thromboembolism and all-cause mortality (n = 44) | |||
| CHA2DS2-VASc score | 1.391 | (1.171, 1.651) | < 0.001 |
| VWF antigen | 1.006 | (1.000, 1.012) | 0.039 |
| Moderate/severe SEC | 0.907 | (0.413, 1.991) | 0.808 |
| LA volume index | 1.023 | (1.005, 1.041) | 0.011 |
| On anticoagulation for > 2 y | 0.885 | (0.366, 2.144) | 0.787 |
| F. Major or clinically relevant nonmajor bleeding and death (n = 41) | |||
| CHA2DS2-VASc score | 1.752 | (1.382, 2.222) | < 0.001 |
| LAAT | 1.155 | (0.293, 4.549) | 0.837 |
| LAA emptying velocity ≤ 25 | 1.830 | (0.745, 4.493) | 0.187 |
| VWF antigen | 1.004 | (0.997, 1.010) | 0.279 |
| On anticoagulation for > 2 y | 1.942 | (0.398, 9.478) | 0.412 |
CHA2DS2-VASc, Congestive Heart Failure, Hypertension, Age (≥75 years), Diabetes, Stroke/Transient Ischemic Attack, Vascular Disease, Age (65-74 years), Sex (Female); CI, confidence interval; LAAT, left atrium appendage thrombus; SEC, spontaneous echocardiographic contrast; VWF, Von Willebrand factor.
For this one evaluation, the proportional hazards P value, calculated using the Supremum test, has not proved the assumption of proportionality (P = 0.044 with the Supremum test). All other evaluations proved the assumption (P > 0.05).