Fig. 3. Box and whisker plots showing meningeal lymphatic marker expression levels in iPSCs derived from individuals with sporadic AD APOE4 (e4/e4) genotype, with parental iPSCs lines edited to E3 (e3/e3) genotype, and cerebral organoids generated from each of the lines.

Normalized gene expression of meningeal lymphatic markers and related genes in cells expressing knock-in of either non-APOE4 (blue) or APOE4 (yellow). Differentially expressed genes are marked with an asterisk to indicate statistical significance: asterisk (*) for false discovery rate (FDR) ≤ 0.05; double asterisks (**) for FDR ≤ 0.01; and triple asterisks (***) for FDR ≤ 0.001. The perpendicular bars represent the standard deviation (SD). Based on reanalysis of data from the published source in [211]. Please note that the scale of the graph may differ between the different depicted genes.